KELAINAN PERKEMBANGAN KRANIOFACIAL FETUS MENCIT (Mus musculus L.) Strain DDW SETELAH PEMBERIAN EKSTRAK N-HEKSAN BUAH ANDALIMAN (Zanthoxylum acanthopodium DC.)

Abstract: The  purpose  of  this  study  is   to  investigate  the  effect  of  n-hexane  extract  of  andaliman  (Zanthoxylum acanthopodium DC.) fruit on craniofacial development of DDW Mice (Mus musculus L.). Experiment was carried  out  using  Completely  Randomized  Design  (CRD)  with  5  treatments  and  6  replicates.  Treatments  consist   of a  blank  control,  vehicle  control  (1%  CMC)  and  3  concentrations  of  andaliman  extract  (2%,  4% and 6%). All treatments were administered by oral gavage (0.1 ml/10 g bw) once  daily from day 0 to day 10 of  gestation.    N-hexane  extract  of  andaliman fruit  induced  developmental  abnormalities in craniofacial structures i.e. increased  the  incidence  of  microphthalmia  (P  <0.05),  and  hydrocephalus  (P  <0.05).  In conclusion, we suggested that andaliman fruit may have fetotoxic effects.

Keyword: andaliman (Zanthoxylum acanthopodium DC.), micropthalmia, hydrocephalus

Penulis: Mai Sarah,  Emita Sabri  dan Salomo Hutahaean 

Kode Jurnal: jpbiologidd120003

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