Abstrak: Research on test teratogenic effects of ethanol extract of leaves of the soursop (Annona muricata L.) have been conducted on white mice fetus. Animal experiments are grouped into 4 group consisting of Group I as a negative control only granted suspension of Na CMC 0.5%, Group II, Group III and Group IV granted soursop leaf ethanol extract at a dose of 250 mg / kg, 500 mg / kg, and 1000 mg / kg once daily from day 6 to day 15 of pregnancy. The 18th day of pregnancy mice were dissected. Results of the study at a dose of 250 mg / kg, a dose of 500 mg / kg, a dose of 1000 mg / kg give teratogen effects. A dose of 250 mg / kg, a dose of 500 mg / kg give teratogen effect with the discovery of skeletal abnormalities. A dose of 1000 mg / kg give teratogen effect with the discovery of late growth. Results showed that the ethanol extract of the leaves of the soursop affect weight loss parent mice were significantly (p <0.05) when compared to the negative control. The quantity of fetuses decreased significantly (p <0.05) when compared to the negative control. Fetal body weight showed a significant effect (p <0.05) when compared to the negative control.
Kata Kunci: Extract Annona Muricata; White Mice; Teratogenic
Penulis: Ifora, Suhatri, Suzie Yolandha
Kode Jurnal: jpfarmasidd160611
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