Abstract: This study aimed to determine the effects of vitamin C and E on liver microstructure of mouse exposed to monosodium glutamate (MSG) for 30 days. The experiment used completely randomized design which consists of 6 treatments and 5 replications. Mice were treated daily by oral gavage with 4 mg MSG (P1), 4 mg MSG + 0.26 mg vitamin C (P2), 4 mg MSG + 0.026 vitamin E (P3), or 4 mg MSG + 0.26 mg vitamin C + 0.026 mg vitamin E (P4). All dosages were based on mg/g body weight. Two control groups K- and K+ were treated with water and castor oil respectively. The mice liver tissue slide was prepared by the paraffin method and stained with haematoxylin-eosin (HE). The results showed that MSG caused cell degeneration and necrosis in liver tissue. Vitamin C and E was able to recover liver cell damage induced by MSG. The highest result was found in P3 and combination treatment (P4) where the recovery effect reaches 64% and 80% respectively.
Keywords: Liver, Monosodium glutamate (MSG), Vitamin C, Vitamin E
Penulis: Ahri Maulida, Syafruddin Ilyas, Salomo Hutahaean
Kode Jurnal: jpbiologidd130041
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